Distinction between intraductal carcinoma of the prostate (IDC-P), high-grade dysplasia (PIN), and invasive prostatic adenocarcinoma, using molecular markers of cancer progression

The Prostate ◽  
2000 ◽  
Vol 44 (4) ◽  
pp. 265-270 ◽  
Author(s):  
Hugh J.S. Dawkins ◽  
Loryn N. Sellner ◽  
Gavin R. Turbett ◽  
Colin A. Thompson ◽  
Sharon L. Redmond ◽  
...  
Keyword(s):  
Molecular Markers ◽  
Cancer Progression ◽  
Prostatic Adenocarcinoma ◽  
High Grade Dysplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Carcinoma Of The Prostate

Intraductal Carcinoma of the Prostate Gland With Transmucosal Spread to the Seminal Vesicle: A Lesion Distinct From High-Grade Prostatic Intraepithelial Neoplasia

2007 ◽  
Vol 131 (7) ◽  
pp. 1122-1125 ◽  
Author(s):  
Ronald J. Cohen ◽  
Beverly A. Shannon ◽  
Sydney L. Weinstein
Keyword(s):  
Seminal Vesicle ◽  
Invasive Carcinoma ◽  
Prostate Gland ◽  
Ejaculatory Duct ◽  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Carcinoma Of The Prostate ◽  
High Stage

Abstract Intraductal carcinoma of the prostate (IDC-P) gland represents an intraluminal neoplastic proliferation that is distinct from high-grade prostatic intraepithelial neoplasia (HG-PIN) and almost always coexists with large-volume, high-stage, and high-grade invasive carcinoma. We document an unusual presentation of apparently “early” IDC-P without an aggressive invasive element that, despite being confined to the acinar-ductal system, has gained access to the ejaculatory duct and seminal vesicle by transmucosal spread. This finding confirms that IDC-P, in contrast to HG-PIN, is inherently aggressive and has the ability to spread beyond the prostate gland. In this case, the absence of an aggressive invasive element suggests that IDC-P has most likely evolved within the lumens directly from HG-PIN.

scholarly journals Cytoplasmic PTEN protein loss distinguishes intraductal carcinoma of the prostate from high-grade prostatic intraepithelial neoplasia

2012 ◽  
Vol 26 (4) ◽  
pp. 587-603 ◽  
Author(s):  
Tamara L Lotan ◽  
Berrak Gumuskaya ◽  
Hameed Rahimi ◽  
Jessica L Hicks ◽  
Tsuyoshi Iwata ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Protein Loss ◽  
Pten Protein ◽  
Carcinoma Of The Prostate

Comparison of prostatic adenocarcinoma Gleason 5 and intraductal carcinoma of the prostate with tumor necrosis. A morphometric study

2018 ◽  
Vol 214 (10) ◽  
pp. 1681-1685 ◽  
Author(s):  
Andres M. Acosta ◽  
Erica Vormittag ◽  
Mohamed R. Haroon Al Rasheed ◽  
Asma Sharif ◽  
Khin-Su Mon ◽  
...  
Keyword(s):  
Tumor Necrosis ◽  
Prostatic Adenocarcinoma ◽  
Intraductal Carcinoma ◽  
Morphometric Study ◽  
Carcinoma Of The Prostate

Pleomorphic Giant Cell Carcinoma of the Prostate

2005 ◽  
Vol 129 (5) ◽  
pp. 683-685 ◽  
Author(s):  
Antonio Lopez-Beltran ◽  
John N. Eble ◽  
David G. Bostwick
Keyword(s):  
Cell Carcinoma ◽  
Giant Cell ◽  
Specific Antigen ◽  
Lumbar Vertebrae ◽  
Prostatic Adenocarcinoma ◽  
High Grade ◽  
Giant Cell Carcinoma ◽  
Carcinoma Of The Prostate ◽  
Pathologic Features ◽  
Pleomorphic Giant Cell Carcinoma

Abstract We report the clinical and pathologic features of 2 cases of pleomorphic giant cell carcinoma of the prostate. One case was found at autopsy in a 77-year-old man and was composed of high-grade prostatic adenocarcinoma with prominent anaplastic giant cells. The patient presented with metastases to multiple retroperitoneal lymph nodes, liver, and lumbar vertebrae. The second case occurred in a 45-year-old man who underwent transurethral resection of the prostate and was found to have high-grade prostatic adenocarcinoma with an extensive anaplastic giant cell component. The patient presented with distant metastases and died within 9 months. Both regular adenocarcinoma and anaplastic giant tumor cells displayed cytoplasmic immunoreactivity for prostate-specific antigen, prostatic acid phosphatase, and keratin AE1/AE3; in one case, scattered cells were also positive for chromogranin and epithelial membrane antigen. Pleomorphic giant cell carcinoma is a rare variant of prostatic adenocarcinoma with a poor prognosis that should be considered in the differential diagnosis of prostatic pleomorphic tumors.

Do Not Misinterpret Intraductal Carcinoma of the Prostate as High-grade Prostatic Intraepithelial Neoplasia!

2012 ◽  
Vol 62 (3) ◽  
pp. 518-522 ◽  
Author(s):  
Rodolfo Montironi ◽  
Marina Scarpelli ◽  
Liang Cheng ◽  
Antonio Lopez-Beltran ◽  
Ming Zhou ◽  
...  
Keyword(s):  
Intraepithelial Neoplasia ◽  
Prostatic Intraepithelial Neoplasia ◽  
Intraductal Carcinoma ◽  
High Grade ◽  
Carcinoma Of The Prostate
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